Diazepam is an anxiolytic drug (tranquilizer) benzodiazepine of number. Diazepam has a pronounced anxiolytic, gipnosedativny, anticonvulsant and muscle relaxant action. The effect of the drug due to the ability of diazepam to potentiate the Central action of gamma-aminomaslana acid – base brake mediator of the Central nervous system. Like all funds number of benzodiazepine diazepam forms a component of functional supramolecular units – receptor complex, the benzodiazepine-gamma-aminomaslana acid–hlorionofor, which is located in the membranes of neurons. Diazepam selectively stimulates the action of gamma-aminobutyric acid receptors in the reticular formation of the column of the brain, resulting in marked reduction of excitation of the cerebral cortex and the thalamus, hypothalamus and limbic system. Muscle relaxant action of diazepam is realized by the braking effect on polysynaptic spinal reflexes. Diazepam enhance the stability of the nervous tissues under hypoxic conditions, and increases pain threshold, inhibits sympathoadrenal and parasympathetic paroxysms. For diazepam typical dose-dependent effect on the Central nervous system: low-dose (2-15 mg / day) have a stimulating effect, and high (more than 15 mg / day) sedative. When receiving diazepam patients noted the reduction of emotional stress, fear, anxiety and worry. On the productive psychotic symptoms Genesis (including hallucinations and delusions) diazepam virtually no effect. Rarely observed decrease in affective tension. In patients with alcohol withdrawal syndrome diazepam reduces the severity of tremor, acute state of agitation, negativism, acute alcoholic delirium and hallucinations. The therapeutic effect of diazepam develops 2-7 days after start of treatment. After oral administration about 75% of the dose absorbed in the digestive tract. Peak plasma concentrations of the active ingredient is celebrated after 60-90 minutes after ingestion, the equilibrium concentrations are established within 1-2 weeks of continuous therapy. About 98% of diazepam is bound to plasma proteins. In the liver almost 99% of diazepam is metabolized to form both active and inactive metabolites. The active ingredient and its metabolites infiltrating through gematoplatzentarnyi barrier and are detected in breast milk. Diazepam is excreted mainly by the kidneys (up to 70% of the dose), less than 10% is excreted in the feces. Excretion occurs in two stages, the half-life of the first stage is 3 hours, second is 48 hours. In elderly patients the elimination half-life may increase to 100 hours in patients with impaired renal function and liver up to 4 days. Also may increase the half-life of diazepam in newborns. When repeated dose of diazepam observed its accumulation in the body.
The maximum recommended dosage of diazepam for adults is one 10mg tablet two to four times daily. If you’re taking diazepam for insomnia, the recommended dose is 5mg to 15mg at bedtime. This dose may have to be reduced for elderly individuals and for individuals suffering from any liver disorders. It is recommended that you consult your healthcare provider to determine the appropriate dose of diazepam for your specific condition.
If you are using diazepam for sleep induction, it is recommended that you take this medicine at bedtime. For other indications, you should take diazepam as directed by your doctor. Swallow the tablets whole, with a glass of water and don’t take diazepam tablets for longer than 4 weeks without a break in order to avoid dependence, unless recommended by your healthcare provider.
The most common side effects of taking Diazepam (Valium) are sleepiness and/or physical tiredness or weakness, lack of co-ordination and balance and dizziness.
As such, do not drive or do other tasks requiring alertness after taking Diazepam.
Conversely, some people experience opposite effects. Instead of becoming calmer, they become nervous, over-excited or agitated after taking Diazepam, and even angry or violent, or have worse insomnia.
For some, instead of Diazepam having muscle relaxing effects, they get cramps and those with seizures may find them worsening.
Another fairly common side effect of Diazepam (Valium) is mental confusion and some memory problems, such as worsened short-term memory and trouble forming new memories. You may also find your breathing feels weaker or shallower and you feel light-headed or faint.
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