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Alprostadil is a medicine used in the treatment of Erectile Dysfunction (impotence). It contains the active ingredient alprostadil. Alprostadil is the same as a naturally occurring chemical called prostaglandin E1. This prostaglandin widens the blood vessels and thins the blood. Alprostadil is used when the blood vessels and nerves in the penis no longer function properly. It increases blood flow, thereby increasing the amount of blood in the penis. Alprostadil is administered by injection directly into the penis. An erection usually occurs between 5 and 10 minutes after injection.

This drug is recommended for people with erectile dysfunction problems. You can also use this medication to preserve a patent ductus arteriosus in the newborn. This is mostly effective when there is a danger of premature ductus arteriosus closure in a baby with ductal-dependent congenital heart disease including acyanotic lesions (that is, interrupted aortic arch, critical aortic stenosis, hypoplastic left heart syndrome, and coarctation of the aorta).

The active ingredient of Vitaros, alprostadil, has a direct effect on the erectile tissue of the penis to cause the blood vessels to dilate, causing an erection. It takes five to 30 minutes to work and normally lasts between one and two hours after application, but the duration of action will vary from patient to patient.

To prepare a dose for administration, remove the ampoule from the foil wrapping. Allow the ampoule contents to warm to room temperature. The ampoule should not be cool to the touch. Do not immerse in water. Do not microwave. Shake the ampoule vigorously for at least 30 seconds. Next, hold the shorter tab closest to the neck of the ampoule and shake it downward with a quick snap to clear any solution from the neck. Holding the ampoule by the edges, twist the top of the ampoule and lift upward to remove it. Make sure the open end of the ampoule does not touch your hands or any other surface.

Alprostadil works by relaxing the muscles, which surround the blood vessels in the penis. This allows blood to flow into the tissues so that an erection may occur. The medicated pellet is inserted into the penis before sex to allow time for the medication to be absorbed into the tissue. The success of the treatment depends on the dose of medication that is administered.

The long-term use of Alprostadil may actually improve a man’s ability to have and to maintain an erection, particularly in cases where the cause is psychological.

Vitaros can cause side effects, although not everybody will find they experience them. Common side effects (may affect more than 1 in 10 patients) include mild to moderate local aching, burning or pain and redness of the penis, rash, itching, swelling, throbbing and numbness. Your partner may experience mild vaginal burning or itching or vaginitis. Use of a latex condom will remove this side effect.

Tell your doctor of your medical history before taking this medication, especially if you have any history of allergies, prolonged erections from other drugs, cancer, physical penis abnormalities, blood or bleeding disorders, low blood pressure, and heart disease. You should also be aware that this drug offers zero protection against sexually transmitted infections such as Hepatitis B or HIV (AIDS).

Overdosing with alprostadil can lead to having a painful and persistent erection for hours on end. If left untreated, this side effect can cause you to have a permanent inability to have an erection. Seek emergency medical attention once you get a prolonged and agonizing erection after using this drug.

Alprostadil has a wide spectrum of pharmacological action. Among the most significant of its effects — vasodilation, inhibition of platelet aggregation, stimulating effect on smooth muscles of intestine, uterus and other smooth muscle organs. Improves microcirculation, increases peripheral blood flow, exerts a vasoprotective effect. With systemic administration causes relaxation of smooth muscle fibers of the vascular wall, has a vasodilatory effect, reduces round, lowers AD. It is noted a reflex increase in cardiac output and heart rate. Helps to improve the elasticity of red blood cells, reduces platelet aggregation and activity of neutrophils, increases the fibrinolytic activity of blood.Smooth muscle cells of the arterial duct have a high sensitivity to the action of alprostadil, which allows its use in newborns with congenital ductus dependent heart defects, including with mitral atresia, atresia of the pulmonary artery, tricuspid valve, tetralogy of Fallot. Alprostadil is used for the palliative treatment before surgery. The use of alprostadil allows you to maintain the ductus arteriosus open, which improves blood circulation and oxygenation. Treatment with alprostadil in this case is basically a short-term measure, but sometimes (when having to postpone surgery) may require prolonged therapy (several months).

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